Opioid receptor activation stimulates normal diet intake but conversely 1 suppresses high - fat diet intake in mice
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چکیده
Title: δ Opioid receptor activation stimulates normal diet intake but conversely 1 suppresses high-fat diet intake in mice 2 3 Kentaro Kaneko, Takafumi Mizushige, Yuri Miyazaki, Michael Lazarus, 4 Yoshihiro Urade, Masaaki Yoshikawa, Ryuhei Kanamoto, Kousaku Ohinata 5 6 Division of Food Science and Biotechnology, Graduate School of Agriculture, Kyoto 7 University, Gokasho Uji, Kyoto 611-0011, Japan; Research Unit for Physiological 8 Chemistry, C-PIER, Kyoto University, Kyoto 606-8501, Japan; Department of 9 Molecular Behavioral Biology, Osaka Bioscience Institute, Suita, Osaka 565-0874, 10 Japan; International Institute for Integrative Sleep Medicine (WPI-IIIS), University of 11 Tsukuba, 1-1-1 Tennodai, Tsukuba, Ibaraki 305-8575, Japan 12 13 Address correspondence to: Kousaku Ohinata PhD, Associate Professor, Division of 14 Food Science and Biotechnology, Graduate School of Agriculture, Kyoto University, 15 Gokasho Uji, Kyoto 611-0011, Japan 16 Tel.: +81-774-38-3733 17 Fax: +81-774-38-3774 18 E-mail: [email protected] 19
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δ-Opioid receptor activation stimulates normal diet intake but conversely suppresses high-fat diet intake in mice.
The central opioid system is involved in a broadly distributed neural network that regulates food intake. Here, we show that activation of central δ-opioid receptor not only stimulated normal diet intake but conversely suppressed high-fat diet intake as well. [D-Pen(2,5)]-enkephalin (DPDPE), an agonist selective for the δ-receptor, increased normal diet intake after central administration to no...
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